Ssc5d Gene Summary [Rat]

Predicted to enable fibronectin binding activity; laminin binding activity; and scavenger receptor activity. Predicted to be involved in negative regulation of interleukin-8 production and response to bacterium. Predicted to act upstream of or within regulation of interleukin-8 production. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human SSC5D (scavenger receptor cysteine rich family member with 5 domains). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Ssc5d
Official Name
scavenger receptor cysteine rich family member with 5 domains [Source:RGD Symbol;Acc:1565772]
Ensembl ID
ENSRNOG00000016687
Bio databases IDs NCBI: 308341 Ensembl: ENSRNOG00000016687
Aliases scavenger receptor cysteine rich family member with 5 domains
Synonyms A430110N23Rik, RGD1565772, S5D-SRCRB, scavenger receptor cysteine rich family, 5 domains, scavenger receptor cysteine rich family member with 5 domains
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ssc5d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Scavenger receptor cysteine-rich domain
  • Family of unknown function (DUF5585)
  • laminin binding
  • scavenger receptor
  • extracellular matrix binding
  • Metaviral_G glycoprotein
  • protein binding
  • fibronectin binding
  • transmembrane receptor
  • Scavenger receptor Cys-rich

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • idiopathic pulmonary fibrosis
regulated by
regulates
  • CXCL8

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Extracellular Space
  • extracellular matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Ssc5d gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle-mediated transport
  • defense response to Gram-negative bacterium
  • innate immune response
  • negative regulation of interleukin-8 production
  • detection of bacterial lipoprotein
  • defense response
  • defense response to Gram-positive bacterium

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • cytoplasm
  • membrane
  • extracellular matrix

Molecular Function

What the gene product does at the molecular level
  • extracellular matrix binding
  • protein binding
  • fibronectin binding
  • scavenger receptor activity
  • laminin binding

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