Ska1 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in establishment of meiotic spindle orientation; nuclear chromosome segregation; and positive regulation of organelle organization. Predicted to be located in several cellular components, including intercellular bridge; kinetochore; and microtubule cytoskeleton. Predicted to be part of SKA complex. Predicted to be active in mitotic spindle and spindle microtubule. Orthologous to human SKA1 (spindle and kinetochore associated complex subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ska1 |
| Official Name | spindle and kinetochore associated complex subunit 1 [Source:RGD Symbol;Acc:1310784] |
| Ensembl ID | ENSRNOG00000015275 |
| Bio databases IDs | |
| Aliases | spindle and kinetochore associated complex subunit 1 |
| Synonyms | 2810433K01Rik, AV117428, C18orf24, RGD1310784, spindle and kinetochore associated complex subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ska1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
- Spindle and kinetochore-associated protein 1, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- metastasis
role in cell
- proliferation
- migration
- survival
- segregation
- invasion by
- chromosomal congression
- misalignment in
- CSN5i-3 sensitivity
- misalignment
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- cilia
- basal bodies
- centrosome
- cytoplasmic bridges
- cytosol
- nucleoplasm
- spindle fibers
- mitotic spindle
- meiotic spindles
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ska1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic sister chromatid segregation
- chromosome segregation
- regulation of microtubule polymerization or depolymerization
- mitotic cell cycle
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- microtubule cytoskeleton
- intercellular bridge
- mitotic spindle
- centriolar satellite
- cytosol
- kinetochore
- condensed chromosome outer kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding