Igf2 Gene Summary [Rat]
Predicted to enable protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf2 |
| Official Name | insulin-like growth factor 2 [Source:RGD Symbol;Acc:2870] |
| Ensembl ID | ENSRNOG00000020369 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 2 |
| Synonyms | C11orf43, GRDF, IGF2 isoform 1, IGF-II, insulin-like growth factor 2, INSULIN-LIKE GROWTH FACTOR II, M6pr, Mpr, Peg2, PP9974, RNIGF2, somatomedin A, SRS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin like growth factor C domain
- insulin like growth factor D domain
- insulin receptor binding
- Insulin-like growth factor II E-peptide
- protein binding
- insulin-like growth factor receptor binding
- growth factor
- protein kinase activator
- transmembrane receptor protein tyrosine kinase activator
- insulin like growth factor B domain
- IGF-1R binding domain
- insulin like growth factor A domain
- Insulin/IGF/Relaxin family
- integrin binding
- IlGF_like
- receptor agonist activity
Pathways
Biological processes and signaling networks where the Igf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- breast cancer
- invasive breast cancer
- hepatocellular carcinoma
- renal cell cancer
- hereditary disorder
- liver cancer
- epithelial cancer
- diabetic nephropathy
role in cell
- cell viability
- survival
- apoptosis
- production in
- differentiation
- cell death
- proliferation
- Gap 0-Gap 1 phase
- G1 phase
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- insulin granule
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- alpha granules
- myelin sheath
- microsomal membrane
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- positive regulation of cell proliferation
- embryonic placenta morphogenesis
- positive regulation of skeletal muscle tissue growth
- positive regulation of mitosis
- positive regulation of transcription from RNA polymerase II promoter
- glucose metabolic process
- positive regulation of glycogen biosynthetic process
- embryonic placenta development
- positive regulation of multicellular organism growth
- negative regulation of transcription from RNA polymerase II promoter
- regulation of muscle cell differentiation
- negative regulation of muscle cell differentiation
- striated muscle cell differentiation
- positive regulation of cell division
- in utero embryonic development
- osteoblast differentiation
- exocrine pancreas development
- genetic imprinting
- positive regulation of insulin receptor signaling pathway
- positive regulation of organ growth
- insulin-like growth factor receptor signaling pathway
- regulation of transcription, DNA-dependent
- positive regulation of MAPK cascade
- positive regulation of activated T cell proliferation
- organ morphogenesis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein serine/threonine kinase activator activity
- transmembrane receptor protein tyrosine kinase activator activity
- integrin binding
- receptor agonist activity
- insulin receptor binding
- hormone activity
- insulin-like growth factor receptor binding