Uimc1 Gene Summary [Rat]
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; nuclear retinoid X receptor binding activity; and ubiquitin-modified histone reader activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in site of double-strand break. Orthologous to human UIMC1 (ubiquitin interaction motif containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uimc1 |
| Official Name | ubiquitin interaction motif containing 1 [Source:RGD Symbol;Acc:1307009] |
| Ensembl ID | ENSRNOG00000016891 |
| Bio databases IDs | |
| Aliases | ubiquitin interaction motif containing 1 |
| Synonyms | 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RETINOID X receptor INTERACTING, RGD1307009, RIP110, Rxrip110, ubiquitin interaction motif containing 1, X2HRIP110 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uimc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- RAP80 N-terminal ubiquitin interaction motif
- SUMO interaction motif
- ubiquitin binding domain
- protein binding activity, bridging
- protein binding
- zinc finger domain
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the Uimc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- insomnia
- systemic lupus erythematosus
- BRCA1 mutation negative BRCA2 mutation negative breast cancer
role in cell
- proliferation
- activation in
- apoptosis
- expression in
- G2/M phase
- G2/M phase transition
- replicative senescence
- degradation in
- recruitment in
- radioresistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uimc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- negative regulation of transcription, DNA-dependent
- regulation of DNA repair
- double-strand break repair
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- nuclear body
- BRCA1-A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- K63-linked polyubiquitin binding
- histone binding
- metal ion binding