UIMC1 Gene Summary [Human]
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | UIMC1 |
| Official Name | ubiquitin interaction motif containing 1 [Source:HGNC Symbol;Acc:HGNC:30298] |
| Ensembl ID | ENSG00000087206 |
| Bio databases IDs | |
| Aliases | ubiquitin interaction motif containing 1, receptor associated protein 80 |
| Synonyms | 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RETINOID X receptor INTERACTING, RGD1307009, RIP110, Rxrip110, ubiquitin interaction motif containing 1, X2HRIP110 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UIMC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- RAP80 N-terminal ubiquitin interaction motif
- SUMO interaction motif
- ubiquitin binding domain
- protein binding activity, bridging
- protein binding
- zinc finger domain
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the UIMC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- insomnia
- systemic lupus erythematosus
- BRCA1 mutation negative BRCA2 mutation negative breast cancer
role in cell
- proliferation
- activation in
- apoptosis
- expression in
- G2/M phase
- G2/M phase transition
- replicative senescence
- degradation in
- recruitment in
- radioresistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UIMC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- negative regulation of transcription, DNA-dependent
- regulation of DNA repair
- double-strand break repair
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- nuclear body
- BRCA1-A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- K63-linked polyubiquitin binding
- histone binding
- metal ion binding