Zfp384 Gene Summary [Rat]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SH3 domain binding activity. Involved in nucleocytoplasmic transport; positive regulation of protein secretion; and positive regulation of transcription by RNA polymerase II. Located in focal adhesion. Orthologous to human ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp384 |
| Official Name | zinc finger protein 384 [Source:RGD Symbol;Acc:708346] |
| Ensembl ID | ENSRNOG00000017066 |
| Bio databases IDs | |
| Aliases | zinc finger protein 384 |
| Synonyms | BB163993, C130073D16Rik, CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1, Zfp384, zinc finger protein 384, ZNF384OS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp384 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- leucine rich domain
- nucleic acid binding
- nuclear localization sequence
- sequence-specific DNA binding
- proline rich domain
- SH3-domain binding
- Sh3 domain binding motif
- zinc finger
- serine-rich region
- polyglutamine-alanine repeat
- double-stranded DNA binding
- Zinc-finger double domain
- AT hook domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- psoriasis
- acute myeloid leukemia
- mixed phenotype acute leukemia
- B-lymphoblastic leukemia/lymphoma
regulated by
- olaparib
- PARP1
role in cell
- number
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- focal adhesions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp384 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription