Sik2 Gene Summary [Rat]
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Predicted to act upstream of or within insulin receptor signaling pathway and protein phosphorylation. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sik2 |
| Official Name | salt-inducible kinase 2 [Source:RGD Symbol;Acc:1559698] |
| Ensembl ID | ENSRNOG00000043498 |
| Bio databases IDs | |
| Aliases | salt-inducible kinase 2 |
| Synonyms | G630080D20Rik, KIAA0781, LOH11CR1I, QIK, RGD1559698, salt-inducible kinase 2, SNF1LK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sik2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- hypertension
- epithelial cancer
- breast carcinoma
- asthma
- respiratory disorder
- primary sclerosing cholangitis
- prostatic carcinoma
role in cell
- apoptosis
- expression in
- degradation in
- binding in
- quantity
- phosphorylation in
- homeostasis
- fusion
- myogenesis by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membranes
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sik2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- regulation of insulin receptor signaling pathway
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity