Npepo Gene Summary [Rat]
Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npepo |
| Official Name | aminopeptidase O [Source:RGD Symbol;Acc:1309592] |
| Ensembl ID | ENSRNOG00000017505 |
| Bio databases IDs | |
| Aliases | aminopeptidase O |
| Synonyms | 2010111I01Rik, 2300006M17Rik, aminopeptidase O, aminopeptidase O (putative), AP-O, C90RF3, C9orf3, DYT31, FLJ14675, mir-23b, mir-24-1, mir-27b, Npepo, ONPEP, RGD1309592 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npepo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase family M1 domain
- leukotriene A-4 hydrolase/aminopeptidase
- peptidase
- Leukotriene A4 hydrolase, C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- breast cancer
- arrhythmia
- epithelial cancer
- breast carcinoma
- prostatic carcinoma
- prostate cancer
- atrial fibrillation
- polycystic ovary syndrome
- dystonia type 31
role in cell
- expression in
- apoptosis
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npepo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloaminopeptidase activity