Bmpr1a Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; BMP binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of cell population proliferation; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including limb morphogenesis; mesoderm morphogenesis; and regionalization. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmpr1a |
| Official Name | bone morphogenetic protein receptor type 1A [Source:RGD Symbol;Acc:70989] |
| Ensembl ID | ENSRNOG00000052469 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein receptor type 1A |
| Synonyms | 10q23del, 1110037I22Rik, ACVRLK3, ALK-3, Bmpr, BMPR-IA, bone morphogenetic protein receptor type 1A, bone morphogenetic protein receptor, type 1A, CD292, JIP, SKR5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmpr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- protein serine/threonine kinase
- protein kinase
- Activin types I and II receptor domain
- cytokine binding
- ATP binding
- Protein kinase domain
- transmembrane receptor protein serine/threonine kinase
- cytoplasmic domain
- intracellular domain
- TFP
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Sleepless protein
- type I transforming growth factor-beta receptor
- transmembrane domain
- protein homodimerization
- Transforming growth factor beta type I GS-motif
Pathways
Biological processes and signaling networks where the Bmpr1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- Osteoarthritis Pathway
- PTEN Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
- TGF-β Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- metastasis
- neoplasia
- tumorigenesis
- juvenile polyposis syndrome
- hereditary cancer-predisposing syndrome
- papillary thyroid carcinoma
- papillary thyroid cancer
- ovarian cancer
- polycystic ovary syndrome
role in cell
- expression in
- growth
- cell death
- apoptosis
- proliferation
- phosphorylation in
- migration
- cell viability
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- plasma membrane extracellular face
- caveolae
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmpr1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- atrioventricular valve development
- regulation of cardiac muscle cell proliferation
- transforming growth factor beta receptor signaling pathway
- central nervous system neuron differentiation
- dorsal/ventral axis specification
- neural plate mediolateral regionalization
- dorsal/ventral pattern formation
- embryonic digit morphogenesis
- endocardial cushion morphogenesis
- epithelial cell proliferation
- immune response
- lateral mesoderm development
- cellular response to BMP stimulus
- in utero embryonic development
- BMP signaling pathway
- atrioventricular node cell development
- dorsal aorta morphogenesis
- mesoderm formation
- positive regulation of epithelial cell proliferation
- positive regulation of bone mineralization
- neural crest cell development
- mitral valve morphogenesis
- tricuspid valve morphogenesis
- embryonic organ development
- positive regulation of mesenchymal cell proliferation
- Mullerian duct regression
- ventricular trabecula myocardium morphogenesis
- ventricular compact myocardium morphogenesis
- pituitary gland development
- cardiac right ventricle morphogenesis
- negative regulation of gene expression
- heart formation
- somitogenesis
- regulation of lateral mesodermal cell fate specification
- cellular response to growth factor stimulus
- positive regulation of transforming growth factor beta2 production
- positive regulation of gene expression
- regulation of cardiac muscle cell apoptotic process
- negative regulation of neurogenesis
- palate development
- outflow tract morphogenesis
- chondrocyte differentiation
- endocardial cushion formation
- odontogenesis of dentin-containing tooth
- ectoderm development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- protein phosphorylation
- outflow tract septum morphogenesis
- negative regulation of muscle cell differentiation
- angiogenesis
- osteoblast differentiation
- somatic stem cell maintenance
- negative regulation of smooth muscle cell migration
- positive regulation of SMAD protein import into nucleus
- mesendoderm development
- hindlimb morphogenesis
- regulation of cellular senescence
- lung development
- cardiac conduction system development
- developmental growth
- ventricular septum morphogenesis
- paraxial mesoderm structural organization
Cellular Component
Where in the cell the gene product is active
- dendrite
- caveola
- membrane
- external side of plasma membrane
- receptor complex
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- BMP binding
- ATP binding
- protein homodimerization activity
- protein binding
- SMAD binding
- metal ion binding
- protein serine/threonine kinase activity
- transforming growth factor beta receptor activity, type I
- transmembrane receptor protein serine/threonine kinase activity