Gpr55 Gene Summary [Rat]
Predicted to enable cannabinoid receptor activity. Predicted to be involved in several processes, including bone resorption; negative regulation of osteoclast differentiation; and positive regulation of intracellular signal transduction. Predicted to be active in plasma membrane. Orthologous to human GPR55 (G protein-coupled receptor 55). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr55 |
| Official Name | G protein-coupled receptor 55 [Source:RGD Symbol;Acc:1559828] |
| Ensembl ID | ENSRNOG00000017521 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 55 |
| Synonyms | CTFL, Gm218, G protein-coupled receptor 55, LPIR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpr55 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- cannabinoid receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr55 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin neoplasia
- pain
- severe myoclonic epilepsy in infancy
- insomnia
- diabetic nephropathy
- COVID-19
- epidermolysis bullosa
- knee osteoarthritis
- fibromyalgia
- postoperative pain
regulated by
- AM 251
- tetradecanoylphorbol acetate
- phytohemagglutinin
- rimonabant
- ibrutinib
- lysophosphatidylinositol
- CP-55940
- anandamide
- endocannabinoid
- cannabidiol
role in cell
- expression in
- growth
- proliferation
- phosphorylation in
- accumulation in
- number
- activation in
- abnormal morphology
- differentiation
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpr55 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- bone resorption
- negative regulation of osteoclast differentiation
- positive regulation of ERK1 and ERK2 cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- cannabinoid receptor activity