Ndufa2 Gene Summary [Rat]
Predicted to act upstream of or within blastocyst hatching. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 13. Orthologous to human NDUFA2 (NADH:ubiquinone oxidoreductase subunit A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa2 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A2 [Source:RGD Symbol;Acc:1309997] |
| Ensembl ID | ENSRNOG00000017571 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A2 |
| Synonyms | B8, C1-B8, CD14, CI-B8, Complex I-B8, MC1DN13, Nadh dehydrogenase(ubiquinone) 1 alpha subcomplex 7, Nadh dehydrogenase(ubiquinone) 1 subcomplex 2, Nadh dehydrogenase(ubiquinone) 1 α subcomplex 7, NADH:ubiquinone oxidoreductase subunit A2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- NADH2 dehydrogenase (ubiquinone)
- Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Pathways
Biological processes and signaling networks where the Ndufa2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 13 mitochondrial complex I deficiency
- cystic leukoencephalopathy
- insulin resistance
- mitochondrial disorder
- Leigh syndrome
- Huntington disease
- paroxysmal nocturnal hemoglobinuria
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- pervasive developmental disorder
role in cell
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- blastocyst hatching
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity