Spns1 Gene Summary [Rat]
Predicted to enable transmembrane transporter activity. Predicted to be involved in lysophospholipid transport and phospholipid efflux. Predicted to act upstream of or within regulation of lysosomal lumen pH. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome and membrane. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spns1 |
| Official Name | sphingolipid transporter 1 [Source:RGD Symbol;Acc:1305613] |
| Ensembl ID | ENSRNOG00000017621 |
| Bio databases IDs | |
| Aliases | sphingolipid transporter 1 |
| Synonyms | 2210013K02Rik, HSpin1, LAT, nrs, PP2030, RGD1305613, SLC62A1, SLC63A1, SPIN1, SPINL, SPNS lysolipid transporter 1, lysophospholipid |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spns1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- Major Facilitator Superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spns1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- regulation of lysosomal lumen pH
- lysophospholipid transport
- phospholipid efflux
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrial inner membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity
- transporter activity