Il12rb1 Gene Summary [Rat]
Predicted to enable coreceptor activity; cytokine binding activity; and cytokine receptor activity. Predicted to contribute to cytokine receptor activity; interleukin-12 receptor binding activity; and interleukin-23 binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; positive regulation of activated T cell proliferation; and positive regulation of defense response to virus by host. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il12rb1 |
| Official Name | interleukin 12 receptor subunit beta 1 [Source:RGD Symbol;Acc:620025] |
| Ensembl ID | ENSRNOG00000019216 |
| Bio databases IDs | |
| Aliases | interleukin 12 receptor subunit beta 1 |
| Synonyms | CD212, IL12RB, IL-12R[b], IL-12R-BETA1, IMD30, interleukin 12 receptor, beta 1, interleukin 12 receptor subunit beta 1, interleukin 12 receptor subunit β 1, interleukin 12 receptor, β 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il12rb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- interleukin-23 receptor
- Fibronectin type 3 domain
- interleukin-23 binding
- cytokine binding module
- FNIII-like repeat
- cytoplasmic domain
- interleukin-12 receptor
- FN3
- interleukin-12 receptor binding
- transmembrane domain
- cytosolic tail domain
- cytokine receptor
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Il12rb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- immunodeficiency 30
- Alzheimer disease
- mouth mucosal ulcer
- tuberculoid leprosy
- systemic lupus erythematosus
- prostate cancer
- susceptibility to tuberculosis
role in cell
- expression in
- activation in
- activity
- phosphorylation in
- proliferation
- chemotaxis
- growth
- function
- development
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il12rb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- interleukin-23-mediated signaling pathway
- positive regulation of defense response to virus by host
- positive regulation of activated T cell proliferation
- positive regulation of T-helper 17 type immune response
- positive regulation of memory T cell differentiation
- cytokine-mediated signaling pathway
- positive regulation of interferon-gamma production
- positive regulation of T-helper 1 type immune response
- positive regulation of T cell mediated cytotoxicity
- cellular response to interferon-gamma
- positive regulation of T-helper 17 cell lineage commitment
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- interleukin-23 receptor complex
- interleukin-12 receptor complex
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-23 binding
- interleukin-12 receptor activity
- interleukin-23 receptor activity
- interleukin-12 receptor binding
- cytokine binding
- cytokine receptor activity