Htr2b Gene Summary [Rat]
Enables serotonin binding activity. Involved in several processes, including cellular response to amine stimulus; cellular response to serotonin; and hepatic stellate cell activation. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr2b |
| Official Name | 5-hydroxytryptamine receptor 2B [Source:RGD Symbol;Acc:61801] |
| Ensembl ID | ENSRNOG00000017625 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 2B |
| Synonyms | 5-HT-2B, 5-HT(2B), 5-HT-2F, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine (serotonin) receptor 2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- palmitoylation site
- intracellular loop
- serotonin binding
- GTPase activator
- protein binding
- 5-HT2 receptor
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- serotonin receptor
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- PDZ binding motif
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- liver cancer
- cancer
- epithelial cancer
- obesity
- impaired glucose tolerance
- psychosis
- obsessive-compulsive disorder
- insomnia
- schizophrenia
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- activation in
- differentiation
- proliferation
- growth
- morphology
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- cGMP-mediated signaling
- protein kinase C signaling cascade
- positive regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- vasoconstriction
- serotonin receptor signaling pathway
- response to xenobiotic stimulus
- regulation of behavior
- heart morphogenesis
- protein kinase B signaling cascade
- phospholipase C-activating serotonin receptor signaling pathway
- positive regulation of nitric-oxide synthase activity
- positive regulation of cell division
- release of sequestered calcium ion into cytosol
- phosphorylation
- positive regulation of phosphatidylinositol biosynthetic process
- calcium-mediated signaling
- neural crest cell differentiation
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- G-protein coupled receptor internalization
- protein kinase C-activating G-protein coupled receptor signaling pathway
- cardiac muscle hypertrophy
- cellular calcium ion homeostasis
- ERK1 and ERK2 cascade
- neural crest cell migration
- embryonic morphogenesis
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- intestine smooth muscle contraction
- cellular response to temperature stimulus
- positive regulation of endothelial cell proliferation
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- Gq/11-coupled serotonin receptor activity
- protein binding
- G-protein alpha-subunit binding
- GTPase activator activity
- neurotransmitter receptor activity
- serotonin receptor activity