Rae1 Gene Summary [Rat]
Predicted to enable RNA binding activity and ubiquitin binding activity. Predicted to be involved in RNA export from nucleus; regulation of mitotic spindle organization; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nuclear envelope. Orthologous to human RAE1 (ribonucleic acid export 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rae1 |
| Official Name | ribonucleic acid export 1 [Source:RGD Symbol;Acc:1311540] |
| Ensembl ID | ENSRNOG00000021295 |
| Bio databases IDs | |
| Aliases | ribonucleic acid export 1 |
| Synonyms | 3230401I12Rik, D2Ertd342e, dJ481F12.3, dJ800J21.1, Gle2, MIG14, MNRP, MNRP41, MRNP41, ribonucleic acid export 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rae1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- WD40
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rae1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- weight loss
- neoplasia
- cachexia
- cataract disease
- colon cancer
- gestational diabetes mellitus
- tumorigenesis
- premature aging
role in cell
- cytotoxicity
- proliferation
- misalignment
- misalignment in
- abnormal morphology
- missegregation
- aneuploidy
- organization
- checkpoint control
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- fibrillar center
- Cytoplasm
- cell surface
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- spindle pole
- interchromatin granule clusters
- nuclear envelope
- kinetochores
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rae1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- cell division
- nucleocytoplasmic transport
- RNA export from nucleus
- cellular response to organic cyclic compound
- regulation of mitotic spindle organization
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- cytoplasm
- fibrillar center
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ubiquitin binding
- microtubule binding