Pnlip Gene Summary [Mouse]
Enables retinyl-palmitate esterase activity and triacylglycerol lipase activity. Involved in retinoid metabolic process. Acts upstream of or within intestinal cholesterol absorption. Predicted to be active in extracellular space. Is expressed in pons and pons mantle layer. Orthologous to human PNLIP (pancreatic lipase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pnlip |
| Official Name | pancreatic lipase [Source:MGI Symbol;Acc:MGI:97722] |
| Ensembl ID | ENSMUSG00000046008 |
| Bio databases IDs | |
| Aliases | pancreatic lipase |
| Synonyms | 1810007A24RIK, LOC108349706, Pancreatic lipase, PANLI, PL, PNLIPD, PTL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pnlip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- colipase binding domain
- alpha/beta hydrolases
- lipase
- PLAT
- enzyme
- retinyl-palmitate esterase
- loop domain
- lipoprotein lipase
- lid domain
- Lipoxygenase homology 2 (beta barrel) domain
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Pnlip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- overweight disorder
- binge eating disorder
- non-insulin-dependent diabetes mellitus
- obesity
- aldosterone producing adrenocortical adenoma
- adenoma formation
- nonalcoholic fatty liver disease
- heart disease
- hepatitis
regulates
- lipid
- triacylglycerol
- cholesterol
- digalactosyldiacylglycerol
- triolein
- retinyl palmitate
- tributyrin
- phosphatidylcholine
- tricaprilin
- retinyl ester
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pnlip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of triglyceride lipase activity
- lipid catabolic process
- lipid metabolic process
- retinol metabolic process
- intestinal cholesterol absorption
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
- triglyceride lipase activity
- lipase activity