Ucn3 Gene Summary [Rat]
Predicted to enable corticotropin-releasing hormone receptor binding activity. Involved in several processes, including cellular response to hypoxia; positive regulation of insulin secretion; and response to corticosterone. Located in axon terminus and varicosity. Orthologous to human UCN3 (urocortin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ucn3 |
| Official Name | urocortin 3 [Source:RGD Symbol;Acc:1562213] |
| Ensembl ID | ENSRNOG00000017759 |
| Bio databases IDs | |
| Aliases | urocortin 3 |
| Synonyms | RGD1562213, SCP, stresscopin, ucn III, urocortin 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ucn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Ucn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hyperglycemia
- major depression
- hyperinsulinism
- reperfusion injury
- diabetic nephropathy
- hypertriglyceridemia
- idiopathic pulmonary fibrosis
role in cell
- production in
- binding in
- expression in
- phosphorylation in
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ucn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of membrane potential
- response to corticosterone stimulus
- response to glucose stimulus
- cellular response to nutrient levels
- digestion
- response to starvation
- response to immobilization stress
- cellular response to hypoxia
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of insulin secretion
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- varicosity
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- protein binding
- corticotropin-releasing hormone receptor binding
- hormone activity