UCN3 Gene Summary [Human]
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | UCN3 |
| Official Name | urocortin 3 [Source:HGNC Symbol;Acc:HGNC:17781] |
| Ensembl ID | ENSG00000178473 |
| Bio databases IDs | |
| Aliases | urocortin 3, stresscopin, prepro-urocortin 3 |
| Synonyms | RGD1562213, SCP, stresscopin, ucn III, urocortin 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UCN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the UCN3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hyperglycemia
- major depression
- hyperinsulinism
- reperfusion injury
- diabetic nephropathy
- hypertriglyceridemia
- idiopathic pulmonary fibrosis
role in cell
- production in
- binding in
- expression in
- phosphorylation in
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UCN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of membrane potential
- response to corticosterone stimulus
- response to glucose stimulus
- cellular response to nutrient levels
- digestion
- response to starvation
- response to immobilization stress
- cellular response to hypoxia
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of insulin secretion
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- varicosity
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- protein binding
- corticotropin-releasing hormone receptor binding
- hormone activity