Ucn3 Gene Summary [Mouse]
This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ucn3 |
| Official Name | urocortin 3 [Source:MGI Symbol;Acc:MGI:1932970] |
| Ensembl ID | ENSMUSG00000044988 |
| Bio databases IDs | |
| Aliases | urocortin 3 |
| Synonyms | RGD1562213, SCP, stresscopin, ucn III, urocortin 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ucn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Ucn3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hyperglycemia
- major depression
- hyperinsulinism
- reperfusion injury
- diabetic nephropathy
- hypertriglyceridemia
- idiopathic pulmonary fibrosis
role in cell
- production in
- binding in
- expression in
- phosphorylation in
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ucn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of membrane potential
- response to corticosterone stimulus
- response to glucose stimulus
- cellular response to nutrient levels
- digestion
- response to starvation
- response to immobilization stress
- cellular response to hypoxia
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of insulin secretion
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- varicosity
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- protein binding
- corticotropin-releasing hormone receptor binding
- hormone activity