Zeb1 Gene Summary [Rat]
Enables chromatin binding activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; and response to activity. Predicted to be located in cytosol and nucleoplasm. Biomarker of acute myocardial infarction and rheumatic heart disease. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zeb1 |
| Official Name | zinc finger E-box binding homeobox 1 [Source:RGD Symbol;Acc:3831] |
| Ensembl ID | ENSRNOG00000017863 |
| Bio databases IDs | |
| Aliases | zinc finger E-box binding homeobox 1 |
| Synonyms | 3110032K11Rik, AREB6, BZP, DELTAEF1, [delta]EF1, FECD6, LOC100996668, MEB1, Nil2, NIL2A, PPCD3, Tcf18, TCF-8, TCP8, TF8, TRANSCRIPTION FACTOR 8, Tw, ZEB, ZFHEP, Zfhep2, ZFHX1A, Zfx1a, Zfx1ha, zinc finger E-box binding homeobox 1, [δ]EF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zeb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- zinc ion binding
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Zeb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- bleeding
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- breast cancer
- androgenic alopecia
role in cell
- quantity
- number
- formation
- formation in
- apoptosis
- survival
- expression in
- phosphorylation in
- glycolysis in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zeb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anatomical structure development
- regulation of smooth muscle cell differentiation
- positive regulation of neuron differentiation
- regulation of T cell differentiation in thymus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of endothelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- cellular response to amino acid stimulus
- forebrain development
- negative regulation of transcription, DNA-dependent
- keratinocyte proliferation
- cochlea morphogenesis
- pattern specification process
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- semicircular canal morphogenesis
- embryonic camera-type eye morphogenesis
- cell differentiation
- response to activity
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of mesenchymal cell proliferation
- response to nutrient levels
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity