Tnfsf12 Gene Summary [Rat]
Predicted to enable receptor ligand activity. Predicted to be involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within positive regulation of protein catabolic process. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to several human genes including TNFSF12 (TNF superfamily member 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf12 |
| Official Name | TNF superfamily member 12 [Source:RGD Symbol;Acc:1359620] |
| Ensembl ID | ENSRNOG00000045670 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 12 |
| Synonyms | APO3L, Dr3l, DR3LG, TNF superfamily member 12, TNLG4A, tumor necrosis factor (ligand) superfamily, member 12, tumour necrosis factor (ligand) superfamily, member 12, TWEAK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfsf12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF homology domain
- cytoplasmic domain
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Tnfsf12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- colitis
- stroke
- breast carcinoma
- chronic obstructive pulmonary disease
- stenosis
- autosomal dominant polycystic kidney disease
- atherosclerosis
- familial hemophagocytic lymphohistiocytosis
- idiopathic meningoencephalitis
role in cell
- phosphorylation in
- expression in
- quantity
- expansion
- signaling in
- number
- loss
- proliferation
- recruitment
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfsf12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- signal transduction
- angiogenesis
- apoptotic process
- extrinsic apoptotic signaling pathway
- cell differentiation
- positive regulation of protein catabolic process
- positive regulation of extrinsic apoptotic signaling pathway
- endothelial cell migration
- positive regulation of endothelial cell proliferation
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- receptor agonist activity
- cytokine activity
- receptor binding