Akr7a3 Gene Summary [Rat]
Enables aldo-keto reductase (NADPH) activity. Involved in aflatoxin catabolic process. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr7a3 |
| Official Name | aldo-keto reductase family 7 member A3 [Source:RGD Symbol;Acc:628635] |
| Ensembl ID | ENSRNOG00000017899 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 7 member A3 |
| Synonyms | AFAR, AFAR2, AFB1-AR2, Aflatoxin B1 Aldehyde Reductase 1, Akr7a1, aldo-keto reductase family 7 member A3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr7a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- Aldo-keto reductase (AKR) superfamily
- binding protein
- NADP binding
- aldo-keto reductase
- Aldo/keto reductase family
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Akr7a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- hepatocellular carcinoma
- late-onset Alzheimer disease
- organismal death
- lung adenocarcinoma formation
- hepatitis C virus-related hepatocellular carcinoma
regulated by
- coumarin
- oltipraz
- diethylmaleate
- 1,2-dithiole-3-thione
- bromobenzene
- N-acetyl-L-cysteine
- TP-235
- aflatoxin B1
- beta-naphthoflavone
- coffee cafestol kahweol mixture
role in cell
- expression in
- molecular cleavage in
- migration
- invasion by
- 5-fluorouracil resistance
- oxaliplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akr7a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular aldehyde metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- electron carrier activity
- aldo-keto reductase (NADP) activity