Stxbp4 Gene Summary [Rat]
Predicted to enable syntaxin binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; positive regulation of keratinocyte proliferation; and protein stabilization. Predicted to act upstream of or within cellular response to type II interferon; protein targeting; and regulation of D-glucose transmembrane transport. Predicted to be located in phagocytic vesicle. Predicted to be active in cytoplasmic vesicle. Orthologous to human STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stxbp4 |
| Official Name | syntaxin binding protein 4 [Source:RGD Symbol;Acc:1307903] |
| Ensembl ID | ENSRNOG00000032768 |
| Bio databases IDs | |
| Aliases | syntaxin binding protein 4 |
| Synonyms | 6030470M02RIK, Synip, syntaxin binding protein 4, Synthaxin binding protein 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stxbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Domain present in PSD-95, Dlg, and ZO-1/2
- TPR/MLP1/MLP2-like protein
- Domain with 2 conserved Trp (W) residues
- WW
- canonical PDZ domain
- coiled-coil domain
- protein binding
- PDZ domain
- WW domain
- syntaxin binding
Pathways
Biological processes and signaling networks where the Stxbp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- schizophrenia
- epithelial cancer
- clonal hematopoiesis
- idiopathic scoliosis
- prostate cancer
- ovarian carcinoma
- epithelial ovarian cancer
- prostatic carcinoma
role in cell
- expression in
- proliferation
- degradation in
- migration
- response by
- regulation in
- maintenance in
- recycling in
- fusion
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stxbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte proliferation
- regulation of insulin secretion involved in cellular response to glucose stimulus
- protein targeting
- regulation of glucose transport
- insulin receptor signaling pathway
- cellular response to interferon-gamma
- protein stabilization
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- phagocytic vesicle
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding