Nup107 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore complex assembly; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup107 |
| Official Name | nucleoporin 107 [Source:RGD Symbol;Acc:621160] |
| Ensembl ID | ENSRNOG00000006541 |
| Bio databases IDs | |
| Aliases | nucleoporin 107 |
| Synonyms | AW541137, C76801, NPHS11, nucleoporin 107, Nucleoporin Nup107, NUP84, ODG6, ODG6 GAMOS7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup107 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- protein binding
- Nuclear pore protein 84 / 107
Pathways
Biological processes and signaling networks where the Nup107 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nephrotic syndrome type 11
- ovarian dysgenesis type 6
- non-insulin-dependent diabetes mellitus
- early onset hypertension
- benign prostatic hyperplasia
- breast cancer
- Galloway-Mowat syndrome 7
- uterine leiomyoma
- leiomyomatosis
- infection by HIV-1
role in cell
- cell death
- assembly
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear pores
- inner nuclear membrane
- outer nuclear membrane
- nuclear rim
- perichromosomal layer
- nuclear envelope
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup107 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- protein import into nucleus
- nephron development
- female gonad development
- nuclear pore complex assembly
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- Nup107-160 complex
- membrane
- cytosol
- kinetochore
- nuclear periphery
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore