Rab8b Gene Summary [Mouse]
Predicted to enable several functions, including GDP binding activity; GTPase activity; and TPR domain binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of corticotropin secretion; and protein import into peroxisome membrane. Located in mitochondrion. Is expressed in brain; liver; and small intestine. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab8b |
| Official Name | RAB8B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:2442982] |
| Ensembl ID | ENSMUSG00000036943 |
| Bio databases IDs | |
| Aliases | RAB8B, member RAS oncogene family |
| Synonyms | 5930437D16, D330025I23RIK, LOC51762, RAB8B, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- protein domain specific binding
- enzyme
- protein binding
- receptor binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab8b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- infection by Dengue virus 2
role in cell
- differentiation
- growth
- formation
- abnormal morphology
- activation
- cross-presentation by
- elimination in
- elimination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- basal compartment
- perinuclear region
- membrane surface
- Plasma Membrane
- Golgi Apparatus
- membrane compartment
- cytosol
- Golgi membrane
- peroxisome membrane
- endosomal membrane
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- cell tip
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab8b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- protein import into peroxisome membrane
- positive regulation of corticotropin secretion
- antigen processing and presentation
- protein secretion
- exocytosis
- endocytic recycling
- positive regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- trans-Golgi network transport vesicle
- phagocytic vesicle
- plasma membrane
- peroxisomal membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- endosome
- cell tip
- phagocytic vesicle membrane
- endosome membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- TPR domain binding
- GTPase activity
- GDP binding
- receptor binding