Fmo5 Gene Summary [Rat]
Enables N,N-dimethylaniline monooxygenase activity. Predicted to be involved in regulation of cholesterol metabolic process and xenobiotic metabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmo5 |
| Official Name | flavin containing dimethylaniline monoxygenase 5 [Source:RGD Symbol;Acc:628602] |
| Ensembl ID | ENSRNOG00000018076 |
| Bio databases IDs | |
| Aliases | flavin containing dimethylaniline monoxygenase 5 |
| Synonyms | 5033418D19RIK, flavin containing dimethylaniline monoxygenase 5, Flavin containing monooxygenase 5, hBVMO1, LOC101060372 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fmo5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- aldehyde oxidase
- NAD(P)-binding Rossmann-like domain
- Pyridine nucleotide-disulphide oxidoreductase
- monooxygenase
- enzyme
- Flavin-binding monooxygenase-like
- dimethylaniline monooxygenase (N-oxide-forming)
Pathways
Biological processes and signaling networks where the Fmo5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual disability and developmental delay
- ulcerative colitis
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- weight gain
- psoriasis
- idiopathic pulmonary fibrosis
- congenital posterior urethral valve disorder
- congenital hypothyroidism
- congenital heart disease
regulates
- D-glucose
- triacylglycerol
- cholesterol
- NADPH
- HDL/cholesterol
- oxygen
- xenobiotic
- LDL/cholesterol
- S-allyl-L-cysteine sulfoxide
- S-allyl-L-cysteine
role in cell
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fmo5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
- lipid metabolic process
- NADPH oxidation
- regulation of cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- NADP binding
- flavin adenine dinucleotide binding
- hypotaurine dehydrogenase activity
- aldehyde oxidase activity
- monooxygenase activity
- N,N-dimethylaniline monooxygenase activity