Ephx1 Gene Summary [Rat]
Enables cis-stilbene-oxide hydrolase activity and enzyme binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and membrane. Biomarker of aflatoxins-related hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ephx1 |
| Official Name | epoxide hydrolase 1 [Source:RGD Symbol;Acc:2557] |
| Ensembl ID | ENSRNOG00000003515 |
| Bio databases IDs | |
| Aliases | epoxide hydrolase 1 |
| Synonyms | EH, Ehm, Eph-1, EPHX, EPOX, Epoxide Hydrolase, epoxide hydrolase 1, epoxide hydrolase 1, microsomal, EPXH1, HYL1, MEH, MEH8, Microsomal Colinesterase, MICROSOMAL EPOXIDE HYDROLASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ephx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- epoxide hydrolase
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- Epoxide hydrolase N terminus
- peptidase
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the Ephx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epilepsy
- liver cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- insulin resistance
- Alzheimer disease
- psoriasis
- tumorigenesis
- glycogen storage disease type II
regulates
- arachidonic acid
- reactive oxygen species
- glycerol
- 2-arachidonoylglycerol
- epoxide
- 14,15-DHET
- acrylamide
- glycol derivative
- 8,9-DHET
- xenobiotic
role in cell
- cell death
- apoptosis
- differentiation
- senescence
- necroptosis
- adipogenesis in
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ephx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epoxide metabolic process
- catabolic process
- xenobiotic metabolic process
- response to organic cyclic compound
- response to toxin
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxysterol binding
- cis-stilbene-oxide hydrolase activity
- epoxide hydrolase activity