Slc12a5 Gene Summary [Rat]
Enables ammonium channel activity and potassium:chloride symporter activity. Involved in several processes, including inorganic cation transmembrane transport; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of postsynapse assembly. Located in dendrite membrane and perikaryon. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34. Orthologous to human SLC12A5 (solute carrier family 12 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc12a5 |
| Official Name | solute carrier family 12 member 5 [Source:RGD Symbol;Acc:620811] |
| Ensembl ID | ENSRNOG00000018111 |
| Bio databases IDs | |
| Aliases | solute carrier family 12 member 5 |
| Synonyms | DEE34, EIEE34, EIG14, hKCC2, KCC2, Kcc2b, Kcc3, mKIAA1176, solute carrier family 12 member 5, solute carrier family 12, member 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc12a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- amino acid permease
- protein binding
- potassium:chloride symporter
- ammonium transporter
- chloride transporter
- transporter
- Solute carrier family 12
- K-Cl cotransporter
Pathways
Biological processes and signaling networks where the Slc12a5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- depressive disorder
- seizures
- edema
- organismal death
- prostate cancer
- major depression
- early infantile epileptic encephalopathy type 34
- heart failure
role in cell
- phosphorylation in
- proliferation
- expression in
- hyperpolarization
- excitation
- synaptic transmission
- long-term potentiation in
- long-term potentiation
- migration
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- extrasynaptic compartment
- glutaminergic synapse
- cell periphery
- somatodendritic region
- membrane surface
- cellular membrane
- Nucleus
- membrane compartment
- perisomatic process
- synaptic membrane
- dendritic spines
- neurites
- myelin sheath
- synapse
- membrane processes
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc12a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- potassium ion homeostasis
- chloride ion homeostasis
- hypotonic response
- synaptic transmission
- response to xenobiotic stimulus
- learning
- cell volume homeostasis
- dendritic spine development
- ion transport
- ammonium transmembrane transport
- intracellular pH reduction
- thermosensory behavior
- cellular chloride ion homeostasis
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- membrane
- synapse
- neuronal cell body
- perikaryon
- neuron projection
- plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- potassium:chloride symporter activity
- ammonium transmembrane transporter activity
- metal ion binding
- chloride transmembrane transporter activity