Pex5l Gene Summary [Rat]
Enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity and small GTPase binding activity. Involved in positive regulation of corticotropin secretion and regulated exocytosis. Located in cell tip and perinuclear region of cytoplasm. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human PEX5L (peroxisomal biogenesis factor 5 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex5l |
| Official Name | peroxisomal biogenesis factor 5-like [Source:RGD Symbol;Acc:708407] |
| Ensembl ID | ENSRNOG00000011211 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 5-like |
| Synonyms | 1700016J08Rik, peroxisomal biogenesis factor 5-like, Pex2, PEX5R, Pex5Rp, PXR2, PXR2B, TRIP8b, Trjip8b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex5l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxisome targeting sequence binding
- peroxisome targeting signal-1 receptor
- Tetratricopeptide repeats
- enzyme binding
- protein binding
- intracellular cyclic nucleotide activated cation channel
- tetratricopeptide repeat
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- multiple sclerosis
- pain
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- function
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- dendrite tip
- perinuclear region
- membrane surface
- cellular membrane
- membrane compartment
- cytosol
- peroxisome membrane
- peroxisomes
- cell tip
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex5l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cAMP-mediated signaling
- protein import into peroxisome matrix, docking
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- cytosol
- receptor complex
Molecular Function
What the gene product does at the molecular level
- peroxisome matrix targeting signal-1 binding
- small GTPase binding
- peroxisome targeting sequence binding