Abce1 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; endoribonuclease inhibitor activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in negative regulation of endoribonuclease activity and translation. Predicted to be located in mitochondrion. Predicted to be active in cytosolic ribosome. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abce1 |
| Official Name | ATP binding cassette subfamily E member 1 [Source:RGD Symbol;Acc:1305301] |
| Ensembl ID | ENSRNOG00000018345 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily E member 1 |
| Synonyms | ABC38, ATP binding cassette subfamily E member 1, ATP-binding cassette, sub-family E member 1, Atp-binding cassette subfamily e member 1a, HuHP68, OABP, RI, RLI, RLI1, RNASEL1, RNASELI, RNS41, RNS4I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abce1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4Fe-4S dicluster domain
- Possible Fer4-like domain in RNase L inhibitor, RLI
- phosphonate ABC transporter, ATP-binding protein
- GTPase
- 4Fe-4S binding domain
- protein binding
- nitrate transport ATP-binding subunits C and D
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- nucleoside-triphosphatase
- LPS export ABC transporter ATP-binding protein
- ribonuclease inhibitor
- ATP-binding cassette protein, ChvD family
- methyl coenzyme M reductase system, component A2
- nickel import ATP-binding protein NikE
- ABC transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- putative bacteriocin export ABC transporter, lactococcin 972 group
- transporter
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
role in cell
- cell viability
- apoptosis
- differentiation
- necroptosis
- survival
- colony formation
- replication in
- dissociation
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- ribosome
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial matrix
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abce1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- ribosomal subunit export from nucleus
- translational termination
- rescue of stalled ribosome
- ribosome disassembly
- negative regulation of endoribonuclease activity
- translational initiation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- mitochondrial matrix
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- CTPase activity
- iron ion binding
- GTPase activity
- ribosomal small subunit binding
- nucleoside-triphosphatase activity
- 4 iron, 4 sulfur cluster binding
- endoribonuclease inhibitor activity