Eif2b3 Gene Summary [Rat]
Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to heat. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif2b3 |
| Official Name | eukaryotic translation initiation factor 2B subunit gamma [Source:RGD Symbol;Acc:620821] |
| Ensembl ID | ENSRNOG00000018375 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2B subunit gamma |
| Synonyms | 1190002P15Rik, EIF-2B, EIF2Bgamma, eukaryotic translation initiation factor 2B, subunit 3, eukaryotic translation initiation factor 2B subunit gamma, eukaryotic translation initiation factor 2B subunit γ, VWM3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif2b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MobA-like NTP transferase domain
- nucleic acid binding translation factor
- I-patch domain
- LbetaH
- guanyl-nucleotide exchange factor
- translation initiation factor
- protein binding
- glycosyltransferase family A
- translation regulator
Pathways
Biological processes and signaling networks where the Eif2b3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- brain infarction
- leukoencephalopathy with vanishing white matter type 3
- leukoencephalopathy with vanishing white matter
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- leukoencephalopathy with vanishing white matter type 1
- adult-onset leukoencephalopathy with vanishing white matter type 3
- Parkinson disease
regulates
- MTORC1
- EIF2B5
role in cell
- expression in
- activation in
- development
- cell survival
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif2b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- response to heat
- response to glucose stimulus
- cytoplasmic translational initiation
- translational initiation
- response to peptide hormone stimulus
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- guanyl-nucleotide exchange factor complex
- eukaryotic translation initiation factor 2B complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- guanyl-nucleotide exchange factor activity
- translation factor activity, nucleic acid binding