Nppb Gene Summary [Rat]
Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of collecting lymphatic vessel constriction. Located in extracellular space and perinuclear region of cytoplasm. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nppb |
| Official Name | natriuretic peptide B [Source:RGD Symbol;Acc:3194] |
| Ensembl ID | ENSRNOG00000008141 |
| Bio databases IDs | |
| Aliases | natriuretic peptide B |
| Synonyms | BNF, BNP, Brain natriuretic peptide, Iso-ANP, Natriuretic factor, natriuretic peptide B, natriuretic peptide type B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nppb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Atrial natriuretic peptide
- diuretic hormone
- hormone
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Nppb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- stroke
- hepatic fibrosis
- early-onset preeclampsia
- organismal death
- left ventricular hypertrophy
- proteinuria
- septic shock
- acute respiratory distress syndrome
- pancreatic ductal adenocarcinoma
role in cell
- apoptosis
- growth
- binding
- activation
- expression in
- inhibition
- chemotaxis
- proliferation
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- perinuclear region
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nppb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- cGMP biosynthetic process
- cGMP-mediated signaling
- cardiac conduction system development
- negative regulation of systemic arterial blood pressure
- receptor guanylyl cyclase signaling pathway
- cell surface receptor signaling pathway
- regulation of vascular permeability
- vasodilation
- protein folding
- regulation of blood pressure
- body fluid secretion
- neuropeptide signaling pathway
- positive regulation of renal sodium excretion
- negative regulation of cell growth
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- macromolecular complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity
- hormone receptor binding
- diuretic hormone activity
- receptor binding