Nup93 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport; nucleus organization; and positive regulation of SMAD protein signal transduction. Located in nuclear envelope. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup93 |
| Official Name | nucleoporin 93 [Source:RGD Symbol;Acc:1311525] |
| Ensembl ID | ENSRNOG00000018564 |
| Bio databases IDs | |
| Aliases | nucleoporin 93 |
| Synonyms | 2410008G02Rik, LOC100039128, NIC96, nucleoporin 93, Nucleoporin Nup93 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup93 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nup93/Nic96
- structural constituent of nuclear pore
- protein binding
Pathways
Biological processes and signaling networks where the Nup93 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- steroid-resistant nephrotic syndrome
- nephrotic syndrome type 12
- nephrosis
- Duchenne muscular dystrophy
role in cell
- cell death
- expression in
- survival
- organization
- interaction in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- centrosome
- cytosol
- nuclear pores
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup93 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- nuclear envelope organization
- protein import into nucleus
- positive regulation of SMAD protein import into nucleus
- nuclear pore complex assembly
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- centrosome
- nuclear membrane
- membrane
- cytosol
- nuclear periphery
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore