Nup205 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup205 |
| Official Name | nucleoporin 205 [Source:RGD Symbol;Acc:1309413] |
| Ensembl ID | ENSRNOG00000010852 |
| Bio databases IDs | |
| Aliases | nucleoporin 205 |
| Synonyms | 3830404O05Rik, C7ORF14, KIAA0225, mKIAA0225, NPHS13, nucleoporin 205, Nucleoporin Nup205, Riken cDNA 3830404o05, Similar to CG11943 gene product |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup205 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- protein binding
- Nuclear pore complex scaffold, nucleoporins 186/192/205
Pathways
Biological processes and signaling networks where the Nup205 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mucopolysaccharidosis, MPS-IV-A
- nephrotic syndrome type 13
- steroid-resistant nephrotic syndrome
- venous thromboembolism
role in cell
- replication in
- expression in
- cell death
- survival
- maintenance
- assembly
- interaction in
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- cytosol
- nuclear pores
- inner nuclear membrane
- nuclear envelope
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup205 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- nuclear pore organization
- protein transport
- nuclear pore complex assembly
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- membrane
- cytosol
- nuclear periphery
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore