Asap1 Gene Summary [Rat]
Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including positive regulation of membrane tubulation; protein localization to cilium; and regulation of postsynapse organization. Predicted to act upstream of or within negative regulation of dendritic spine development. Predicted to be located in several cellular components, including Golgi apparatus; centriolar satellite; and dendritic spine. Predicted to be active in glutamatergic synapse and podosome. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asap1 |
| Official Name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [Source:RGD Symbol;Acc:1307379] |
| Ensembl ID | ENSRNOG00000058733 |
| Bio databases IDs | |
| Aliases | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
| Synonyms | AMAP1, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1, AV239055, CENTB4, DDEF1, DEF-1, LOC100039024, mKIAA1249, PAG2, PAP, s19, ZG14P |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src binding domain
- RXXs motif
- Ankyrin repeats (many copies)
- GTPase activator
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- proline rich domain
- Arf-GAP domain
- PXsP motif
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- Serine Proline motif
- Putative GTPase activating protein for Arf
- ankyrin repeats
- phospholipid binding
- FAK binding domain
- Ankyrin repeats (3 copies)
- protein binding
- Pleckstrin homology-like domain
- phosphorylation site
- Src Homology 3 domain superfamily
- BAR domain of APPL family
- binding protein
- Putative GTP-ase activating proteins for the small GTPase, ARF
- BAR domain
Pathways
Biological processes and signaling networks where the Asap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- dementia
- cutaneous melanoma
- multiple sclerosis
- cutaneous melanoma cancer
- progressive supranuclear palsy
- metastasis
- refractive error
- tuberculosis
- psychoticism
role in cell
- formation
- migration
- activation in
- motility
- cell spreading
- development
- morphology
- invasion
- assembly
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- invadopodia
- cellular membrane
- focal adhesions
- podosomes
- centrosome
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- negative regulation of dendritic spine development
- Golgi to plasma membrane protein transport
- positive regulation of flagellum assembly
Cellular Component
Where in the cell the gene product is active
- dendritic spine
- cytosol
- Golgi membrane
- trans-Golgi network membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding
- metal ion binding
- cadherin binding
- GTPase activator activity