Vps16 Gene Summary [Rat]
Enables actin filament binding activity. Predicted to be involved in autophagosome maturation and endosome to lysosome transport. Predicted to act upstream of or within symbiont entry into host cell. Located in axon; endosome; and neuronal cell body. Is active in presynapse. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps16 |
| Official Name | VPS16 core subunit of CORVET and HOPS complexes [Source:RGD Symbol;Acc:1359414] |
| Ensembl ID | ENSRNOG00000021222 |
| Bio databases IDs | |
| Aliases | VPS16 core subunit of CORVET and HOPS complexes |
| Synonyms | 1810074M16Rik, DYT30, hVPS16, mVPS16, VPS16 core subunit of CORVET and HOPS complexes, VSP16 CORVET/HOPS core subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Vps16, N-terminal region
- Vps16, C-terminal region
- actin binding
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Vps16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- prostate cancer
- dystonia type 30
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
regulates
role in cell
- replication in
- entrance
- autophagy
- autophagy in
- recycling in
- dipeptide repeat protein sensitivity
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- presynaptic regions
- cell periphery
- cellular membrane
- endosomes
- vesicles
- lysosome
- actin filaments
- cytosol
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- perikaryon
- axons
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- endosomal transport
- vacuole fusion, non-autophagic
- endosome to lysosome transport
- endosomal vesicle fusion
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- CORVET complex
- late endosome
- autophagic vacuole
- lysosomal membrane
- lysosome
- late endosome membrane
- early endosome
- endosome
- recycling endosome
- endosome membrane
- clathrin-coated vesicle
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding