Amacr Gene Summary [Rat]
Enables alpha-methylacyl-CoA racemase activity. Involved in bile acid biosynthetic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amacr |
| Official Name | alpha-methylacyl-CoA racemase [Source:RGD Symbol;Acc:3048] |
| Ensembl ID | ENSRNOG00000018662 |
| Bio databases IDs | |
| Aliases | alpha-methylacyl-CoA racemase |
| Synonyms | 2-Methylacyl-CoA Racemase, alpha-methylacyl-CoA racemase, AMACRD, CBAS4, Da1-8, Macr1, Marc1, P504S, RACE, RM, α-methylacyl-CoA racemase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Amacr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mesaconyl-CoA isomerase
- CoA-transferase family III
- enzyme
- receptor binding
- alpha-methylacyl-CoA racemase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- epithelial cancer
- liver cancer
- congenital bile acid synthesis defect type 4
- alpha-methylacyl-CoA racemase deficiency
- hereditary disorder
- prostate cancer
- renal cell cancer
- hepatitis B virus-related hepatocellular carcinoma
- weight loss
role in cell
- proliferation
- production in
- growth
- G2/M phase
- racemization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- Plasma Membrane
- Mitochondria
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Amacr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation using acyl-CoA oxidase
- bile acid biosynthetic process
- bile acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- peroxisomal matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- alpha-methylacyl-CoA racemase activity