Pou4f3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; neuromuscular process controlling balance; and sensory perception of sound. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Orthologous to human POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou4f3 |
| Official Name | POU class 4 homeobox 3 [Source:RGD Symbol;Acc:1310459] |
| Ensembl ID | ENSRNOG00000018842 |
| Bio databases IDs | |
| Aliases | POU class 4 homeobox 3 |
| Synonyms | Brn3.1, BRN3C, ddl, DFNA15, DFNA42, DFNA52, dreidel, OCT-T3, POU class 4 homeobox 3, POU domain, class 4, transcription factor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pou4f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- hearing loss
- autosomal dominant deafness type 15
- familial nonsyndromic hearing impairment
- germ cell neoplasia
- autosomal recessive deafness
- autosomal recessive sensorineural hearing loss
- yolk sac neoplasm
role in cell
- migration
- apoptosis
- differentiation
- formation
- quantity
- degeneration
- outgrowth
- lack
- extension
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pou4f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- retinal ganglion cell axon guidance
- auditory receptor cell differentiation
- axon extension
- inner ear morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- visual perception
- vestibulocochlear nerve development
- neuromuscular process controlling balance
- neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity