Pou4f3 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neuromuscular process controlling balance; and sensory perception of sound. Located in nucleus. Is expressed in several structures, including genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Orthologous to human POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou4f3 |
| Official Name | POU domain, class 4, transcription factor 3 [Source:MGI Symbol;Acc:MGI:102523] |
| Ensembl ID | ENSMUSG00000024497 |
| Bio databases IDs | |
| Aliases | POU domain, class 4, transcription factor 3 |
| Synonyms | Brn3.1, BRN3C, ddl, DFNA15, DFNA42, DFNA52, dreidel, OCT-T3, POU class 4 homeobox 3, POU domain, class 4, transcription factor 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou4f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- hearing loss
- autosomal dominant deafness type 15
- familial nonsyndromic hearing impairment
- germ cell neoplasia
- autosomal recessive deafness
- autosomal recessive sensorineural hearing loss
- yolk sac neoplasm
phenotypes
- abnormal Deiters cell morphology
- abnormal autonomic nervous system physiology
- abnormal basilar membrane morphology
- abnormal body temperature homeostasis
- abnormal circadian temperature homeostasis
- abnormal cochlea morphology
- abnormal cochlear ganglion morphology
- abnormal cochlear hair cell development
- abnormal cochlear inner hair cell morphology
- abnormal cochlear outer hair cell morphology
- abnormal cochlear sensory epithelium morphology
- abnormal crista ampullaris neuroepithelium morphology
- abnormal cuticular plate morphology
- abnormal energy expenditure
- abnormal gait
- abnormal inner ear vestibule morphology
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal organ of Corti morphology
- abnormal organ of Corti supporting cell differentiation
- abnormal outer hair cell stereociliary bundle morphology
- abnormal pillar cell differentiation
- abnormal sensory neuron innervation pattern
- abnormal utricle morphology
- abnormal vestibular hair cell development
- abnormal vestibular hair cell morphology
- abnormal vestibular hair cell stereociliary bundle morphology
- abnormal vestibular system physiology
- abnormal vestibulocochlear ganglion morphology
- absent Deiters cells
- absent cochlear hair cell stereocilia
- absent cochlear hair cells
- absent cochlear inner hair cells
- absent cochlear outer hair cells
- absent inner hair cell stereocilia
- absent organ of Corti supporting cells
- absent outer hair cell stereocilia
- absent pillar cells
- absent pinna reflex
- absent tunnel of Corti
- absent vestibular hair cell stereocilia
- absent vestibular hair cells
- circling
- cochlear ganglion degeneration
- cochlear hair cell degeneration
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
- conductive hearing loss
- deafness
- decreased body size
- decreased body weight
- decreased startle reflex
- decreased vestibular hair cell number
- degeneration of organ of Corti supporting cells
- head bobbing
- head tossing
- hyperactivity
- impaired balance
- impaired swimming
- increased or absent threshold for auditory brainstem response
- mixed hearing loss
- no abnormal phenotype detected
- organ of Corti degeneration
- pillar cell degeneration
- premature death
- reduced fertility
- sensorineural hearing loss
- small Rosenthal canal
- small cochlear ganglion
- small vestibular ganglion
- stria vascularis degeneration
- vestibular ganglion degeneration
- vestibular hair cell degeneration
- weight loss
role in cell
- migration
- apoptosis
- differentiation
- formation
- quantity
- degeneration
- outgrowth
- lack
- extension
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou4f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- retinal ganglion cell axon guidance
- auditory receptor cell differentiation
- axon extension
- inner ear morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- visual perception
- vestibulocochlear nerve development
- neuromuscular process controlling balance
- neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity