Pla2g10 Gene Summary [Rat]
Enables phospholipase A2 activity. Predicted to be involved in several processes, including cholesterol homeostasis; glycerophospholipid metabolic process; and positive regulation of lipid localization. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; erythrocyte maturation; and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in acrosomal vesicle and extracellular space. Orthologous to human PLA2G10 (phospholipase A2 group X). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g10 |
| Official Name | phospholipase A2, group X [Source:RGD Symbol;Acc:61935] |
| Ensembl ID | ENSRNOG00000003164 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group X |
| Synonyms | GXPLA2, GXSPLA2, LOC105371095, phospholipase A2 group X, phospholipase A2, group X, PLA2GX, SPLA2, sPLA2-X |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-alkyl-2-acetylglycerophosphocholine esterase
- calcium-dependent phospholipase A2
- enzyme
- protein binding
- phospholipase A2
- phospholipase
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- hyperplasia
- preeclampsia
- lymphopenia
- metaplasia
- airway hyperresponsiveness
- dextran sodium sulfate-induced colitis
- usual interstitial pneumonia
- alopecia
- cardiac fibrosis
role in cell
- function
- migration
- cellular infiltration by
- phosphorylation in
- expression in
- production in
- quantity
- accumulation
- number
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- Extracellular Space
- Golgi Apparatus
- cytosol
- acrosome
- neurofilaments
- growth cone
- neurites
- azurophil granules
- cell membrane leading edge
- perikaryon
- A fibers
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of arachidonic acid secretion
- low-density lipoprotein particle remodeling
- axon guidance
- phosphatidylethanolamine metabolic process
- negative regulation of cytokine production involved in inflammatory response
- phospholipid metabolic process
- negative regulation of cholesterol efflux
- cholesterol homeostasis
- macrophage activation
- erythrocyte maturation
- production of molecular mediator involved in inflammatory response
- positive regulation of prostaglandin secretion
- positive regulation of protein metabolic process
- phosphatidylserine metabolic process
- regulation of macrophage activation
- defense response to virus
- arachidonic acid metabolic process
- negative regulation of inflammatory response
- fertilization
- negative regulation of sequence-specific DNA binding transcription factor activity
- phosphatidylglycerol metabolic process
- phosphatidylcholine catabolic process
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- phosphatidic acid metabolic process
- prostaglandin biosynthetic process
- positive regulation of acrosome reaction
- hair follicle morphogenesis
- positive regulation of macrophage derived foam cell differentiation
- lysophospholipid transport
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- extracellular space
- acrosomal vesicle
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- protein binding
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- phospholipid binding
- phospholipase activity