Dnajc1 Gene Summary [Rat]
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in regulation of protein secretion. Predicted to act upstream of or within protein folding and regulation of translation. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endomembrane system. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc1 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C1 [Source:RGD Symbol;Acc:2322144] |
| Ensembl ID | ENSRNOG00000000150 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C1 |
| Synonyms | 4733401K02RIK, D230036H06RIK, DnaJ heat shock protein family (Hsp40) member C1, DNAJL1, ERdj1, ERj1p, HTJ1, LOC100504126, MTJ1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnajc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- SANT
- DnaJ
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- DnaJ molecular chaperone homology domain
- Myb-like DNA-binding domain
- ribosome binding
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Dnajc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- organismal death
- acute lung injury
- insomnia
- breast carcinoma
- endometriosis
- essential hypertension
role in cell
- expression in
- proliferation
- migration
- apoptosis
- invasion by
- translation in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- microsome
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnajc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of protein secretion
- negative regulation of proteolysis
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- endomembrane system
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chaperone binding
- ATPase activator activity