Armc4 Gene Summary [Rat]
Predicted to act upstream of or within several processes, including outer dynein arm assembly; regulation of cilium beat frequency; and ventricular system development. Predicted to be located in axoneme and ciliary base. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Armc4 |
| Official Name | armadillo repeat containing 4 [Source:RGD Symbol;Acc:1306933] |
| Ensembl ID | ENSRNOG00000018905 |
| Bio databases IDs | |
| Aliases | armadillo repeat containing 4 |
| Synonyms | 4930463I21RIK, ARMC4, b2b227.1Clo, b2b643Clo, CILD23, ddx5-ps1, gudu, outer dynein arm docking complex subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Armc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Armadillo/beta-catenin-like repeats
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary ciliary dyskinesia type 23
- hypertension
- primary ciliary dyskinesia
- epithelial cancer
- congenital heart disease
- cardiovascular disorder
- prostatic carcinoma
- prostate cancer
- retinal detachment
regulates
- Axonemal Dynein Outer Arm
role in cell
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Armc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- heart development
- outer dynein arm assembly
- cilium movement
- determination of left/right symmetry
- regulation of cilium beat frequency
Cellular Component
Where in the cell the gene product is active
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding