Med13 Gene Summary [Rat]
Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in cholesterol homeostasis; regulation of DNA-templated transcription; and triglyceride homeostasis. Predicted to be located in nucleoplasm. Predicted to be part of CKM complex and mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 61. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med13 |
| Official Name | mediator complex subunit 13 [Source:RGD Symbol;Acc:1304829] |
| Ensembl ID | ENSRNOG00000003679 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 13 |
| Synonyms | 1110067M05RIK, ARC250, D030023K18, DRIP250, HSPC221, mediator complex subunit 13, MRD61, THARP1, THRAP1, Thyroid Hormone Associated Protein 1, TRAP240 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Med13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator complex subunit 13 N-terminal
- transcription regulator
- transcription co-activator
- MID domain of medPIWI
- transcription cofactor
- Mediator complex subunit 13 C-terminal domain
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the Med13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hepatic steatosis
- hereditary disorder
- intellectual developmental disorder 61
- Parkinson disease
- complex neurodevelopmental disorder
- autosomal dominant isolated somatotropin deficiency
- neurodevelopmental disorder
- focal cortical dysplasia of Taylor
role in cell
- expression in
- proliferation
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Med13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription initiation from RNA polymerase II promoter
- triglyceride homeostasis
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding