Odad2 Gene Summary [Mouse]
Acts upstream of or within several processes, including determination of left/right symmetry; outer dynein arm assembly; and ventricular system development. Predicted to be located in axoneme and ciliary base. Is expressed in node. Used to study Kartagener syndrome; primary ciliary dyskinesia 23; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Odad2 |
| Official Name | outer dynein arm docking complex subunit 2 [Source:MGI Symbol;Acc:MGI:1922184] |
| Ensembl ID | ENSMUSG00000061802 |
| Bio databases IDs | |
| Aliases | outer dynein arm docking complex subunit 2 |
| Synonyms | 4930463I21RIK, ARMC4, b2b227.1Clo, b2b643Clo, CILD23, ddx5-ps1, gudu, outer dynein arm docking complex subunit 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Odad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Armadillo/beta-catenin-like repeats
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Axonemal Dynein Outer Arm
disease
- primary ciliary dyskinesia type 23
- hypertension
- primary ciliary dyskinesia
- epithelial cancer
- congenital heart disease
- cardiovascular disorder
- prostatic carcinoma
- prostate cancer
- retinal detachment
role in cell
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Odad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- heart development
- outer dynein arm assembly
- cilium movement
- determination of left/right symmetry
- regulation of cilium beat frequency
Cellular Component
Where in the cell the gene product is active
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding