Fa2h Gene Summary [Rat]
Enables fatty acid 2-hydroxylase activity. Involved in galactosylceramide biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fa2h |
| Official Name | fatty acid 2-hydroxylase [Source:RGD Symbol;Acc:1310347] |
| Ensembl ID | ENSRNOG00000018950 |
| Bio databases IDs | |
| Aliases | fatty acid 2-hydroxylase |
| Synonyms | FAAH, FAH1, fatty acid 2-hydroxylase, FAXDC1, G630055L08Rik, LOC688373, RGD1310347, SCS7, SPG35, Wdr59 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fa2h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fatty acid hydroxylase
- monophenol:oxygen oxidoreductase
- Cytochrome b5-like Heme/Steroid binding domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- autosomal recessive spastic paraplegia type 35 with neurodegeneration
- spastic paraplegia
- autosomal recessive spastic paraplegia type 35
- neurodegeneration with brain iron accumulation
- lung adenocarcinoma
- edema
- lung adenocarcinoma formation
- organismal death
role in cell
- expression in
- phosphorylation in
- proliferation
- degeneration
- cell viability
- binding in
- migration
- differentiation
- cytotoxicity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fa2h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system myelin maintenance
- ceramide biosynthetic process
- galactosylceramide biosynthetic process
- fatty acid biosynthetic process
- establishment of skin barrier
- fatty acid metabolic process
- regulation of hair cycle
- glucosylceramide biosynthetic process
- peripheral nervous system myelin maintenance
- sebaceous gland cell differentiation
- sphingolipid biosynthetic process
- lipid modification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- fatty acid alpha-hydroxylase activity
- heme binding