Ngfr Gene Summary [Rat]
Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TRKA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Is active in neuromuscular junction and presynaptic membrane. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including alcohol dependence; brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease and depressive disorder. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ngfr |
| Official Name | nerve growth factor receptor [Source:RGD Symbol;Acc:3177] |
| Ensembl ID | ENSRNOG00000005392 |
| Bio databases IDs | |
| Aliases | nerve growth factor receptor |
| Synonyms | CD271, FL-P75NTR, fNGFR, Gp80-LNGFR, LNGFR, nerve growth factor receptor, nerve growth factor receptor (TNFR superfamily, member 16), Ngf Receptor Subtype1, Np75, p75, p75lnfgr, p75LNGFR, p75 NEUROTROPHIN receptor, p75NGFR, p75NTR, p75(NTR), RNNGFRR, TNFRSF16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ngfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- identical protein binding
- cytoplasmic domain
- intracellular domain
- tail domain
- membrane-proximal domain
- transmembrane receptor
- cysteine rich domain
- growth factor binding
- coreceptor
- extracellular domain
- ubiquitin protein ligase binding
- signaling receptor activity
- death receptor
- calmodulin binding
- ectodomain
- TNFR/NGFR cysteine-rich region
- enzyme binding
- linker domain
- beta-amyloid binding
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- neurotrophin TRKA receptor binding
- binding protein
- stalk region
- transmembrane domain
- cytosolic tail domain
- PDZ binding motif
- Death Domain Superfamily of protein-protein interaction domains
- Tumor necrosis factor receptor member 16 trans-membrane domain
Pathways
Biological processes and signaling networks where the Ngfr gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Autophagy
- CDK5 Signaling
- Ceramide Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- Hepatic Cholestasis
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Myc Mediated Apoptosis Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- NGF Signaling
- PPAR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- PTEN Signaling
- Role of Tissue Factor in Cancer
- STAT3 Pathway
- T Helper Cell Differentiation
- Tight Junction Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- gastric cancer
- esophageal squamous cell carcinoma
- breast cancer
- cardiomyopathy
- Alzheimer disease
- multiple sclerosis
- age-related hearing loss
- hyperactive behavior
role in cell
- cell viability
- expression in
- activation in
- phosphorylation in
- proliferation
- binding in
- accumulation in
- growth
- invasion by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- synaptic spine
- basal dendrites
- primary dendrite
- tertiary dendrite
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- endosomes
- Golgi Apparatus
- Mitochondria
- intercellular junctions
- cytosol
- apical cell surfaces
- plasma membrane extracellular face
- caveolar membranes
- apical membrane
- presynaptic membrane
- caveolae
- basolateral membrane
- nucleoplasm
- nuclear envelope
- neuromuscular junctions
- growth cone
- neurites
- nerve ending
- dendrite initial segments
- endocytotic vesicle
- membrane rafts
- membrane processes
- microvilli
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- Merkel nerve endings
- axonal shafts
- melanin granules
- corticothalamic axons
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ngfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- negative regulation of fibroblast growth factor receptor signaling pathway
- axon guidance
- fibroblast growth factor receptor signaling pathway
- odontogenesis of dentin-containing tooth
- Rho protein signal transduction
- positive regulation of odontogenesis of dentin-containing tooth
- intracellular protein transport
- nerve development
- dorsal aorta development
- fibroblast proliferation
- circadian regulation of gene expression
- central nervous system development
- cellular glucose homeostasis
- positive regulation of fibroblast proliferation
- glucose homeostasis
- hair follicle morphogenesis
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- detection of temperature stimulus
- negative regulation of cell migration
- neuron apoptotic process
- negative regulation of hair follicle development
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular region
- perikaryon
- plasma membrane
- nucleoplasm
- cell surface
- growth cone
- endosome
- cell-cell junction
- membrane
- dendritic spine
- cytosol
- neuromuscular junction
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- calmodulin binding
- ubiquitin protein ligase binding
- transmembrane signaling receptor activity
- protein binding
- neurotrophin binding
- signaling receptor activity
- small GTPase binding
- death receptor activity
- beta-amyloid binding
- nerve growth factor binding