Acat2 Gene Summary [Rat]
Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including cellular response to fatty acid; ketone body catabolic process; and liver development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acat2 |
| Official Name | acetyl-CoA acetyltransferase 2 [Source:RGD Symbol;Acc:1359366] |
| Ensembl ID | ENSRNOG00000019189 |
| Bio databases IDs | |
| Aliases | acetyl-CoA acetyltransferase 2 |
| Synonyms | Ab2-076, Acat3, Acetoacetyl Coa Thiolase, ACETOCOENZYME A ACETYLTRANSFERASE 2, acetyl-CoA acetyltransferase 2, LOC678796, Similar to tcp1x, Tcp-x1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- 3-oxoadipyl-CoA thiolase
- cond_enzymes
- acetyl-CoA acetyltransferases
- fatty oxidation complex, beta subunit FadA
- acetyl-CoA C-acetyltransferase
- Thiolase, C-terminal domain
- enzyme
- protein binding
- Beta-ketoacyl synthase, C-terminal domain
Pathways
Biological processes and signaling networks where the Acat2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- allergic rhinitis
- coronary artery disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- acetyl-CoA acetyltransferase 2 deficiency
role in cell
- differentiation
- esterification in
- signaling in
- accumulation in
- size
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- protein binding