ACAT2 Gene Summary [Human]
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ACAT2 |
| Official Name | acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94] |
| Ensembl ID | ENSG00000120437 |
| Bio databases IDs | |
| Aliases | acetyl-CoA acetyltransferase 2, acetoacetyl Coenzyme A thiolase, Acetyl-CoA acetyltransferase, cytosolic |
| Synonyms | Ab2-076, Acat3, Acetoacetyl Coa Thiolase, ACETOCOENZYME A ACETYLTRANSFERASE 2, acetyl-CoA acetyltransferase 2, LOC678796, Similar to tcp1x, Tcp-x1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACAT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- 3-oxoadipyl-CoA thiolase
- cond_enzymes
- acetyl-CoA acetyltransferases
- fatty oxidation complex, beta subunit FadA
- acetyl-CoA C-acetyltransferase
- Thiolase, C-terminal domain
- enzyme
- protein binding
- Beta-ketoacyl synthase, C-terminal domain
Pathways
Biological processes and signaling networks where the ACAT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- allergic rhinitis
- coronary artery disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- acetyl-CoA acetyltransferase 2 deficiency
role in cell
- differentiation
- esterification in
- signaling in
- accumulation in
- size
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACAT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- protein binding