Psme2 Gene Summary [Rat]
Predicted to enable endopeptidase activator activity and identical protein binding activity. Predicted to be involved in regulation of G1/S transition of mitotic cell cycle and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME2 (proteasome activator subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psme2 |
| Official Name | proteasome activator subunit 2 [Source:RGD Symbol;Acc:3430] |
| Ensembl ID | ENSRNOG00000019246 |
| Bio databases IDs | |
| Aliases | proteasome activator subunit 2 |
| Synonyms | 11S PROTEASOME beta subunit, 11S PROTEASOME β subunit, AI788882, LT629152.7, PA28B, PA28beta, Pa28 β, proteasome activator subunit 2, proteasome (prosome, macropain) activator subunit 2 (PA28 beta), proteasome (prosome, macropain) activator subunit 2 (PA28 β), PSMA28, REGbeta |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psme2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- enzyme regulator activity
- protease activator
- Proteasome activator pa28 beta subunit
- identical protein binding
- Proteasome activator pa28 alpha subunit
Pathways
Biological processes and signaling networks where the Psme2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lichen planus
- psoriasis
- celiac disease
- delayed hypersensitive reaction
- limited systemic sclerosis
- infection by HIV-1
role in cell
- growth
- activation
- cytolysis by
- function
- immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psme2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- proteasome complex
- proteasome activator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- identical protein binding
- protein binding