Pcdh12 Gene Summary [Rat]

Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and labyrinthine layer development. Predicted to be located in cell-cell junction. Predicted to be active in plasma membrane. Orthologous to human PCDH12 (protocadherin 12). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Pcdh12
Official Name
protocadherin 12 [Source:RGD Symbol;Acc:619917]
Ensembl ID
ENSRNOG00000019265
Bio databases IDs NCBI: 116808 Ensembl: ENSRNOG00000019265
Aliases protocadherin 12
Synonyms DMJDS1, Pcdh14, protocadherin 12, VECAD2, VE-cadherin-2
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcdh12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin-like
  • Cadherin repeat-like domain

Pathways

Biological processes and signaling networks where the Pcdh12 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • papillomatosis
  • COVID-19
  • squamous cell cancer
  • diencephalic-mesencephalic junction dysplasia syndrome 1
  • gout
  • squamous-cell carcinoma
  • preeclampsia
  • diencephalic-mesencephalic junction dysplasia
  • papilloma
regulated by
  • cyclic AMP
  • prostaglandin E2
  • histamine
  • PI3K (complex)
  • gefitinib
  • PKC
  • VEGF
  • Secretase gamma
  • Adam-10
regulates
  • glycogen
role in cell
  • adhesion
  • aggregation
  • recognition

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • intercellular junctions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Pcdh12 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • glycogen metabolic process
  • neuron recognition
  • cell adhesion
  • homophilic cell adhesion
  • labyrinthine layer development

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • cell-cell junction
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding